Lead Scientist in Statistical genomics and Systems biology
Institute
of Biological Psychiatry at Mental Health Services, Copenhagen and University
of Copenhagen is building an international and highly competitive research
environment, and is seeking an internationally leading capacity to head the
work on statistical genomics and systems biology of severe mental disorders.
The position is available from March 1, 2018 and initially limited to three
years.
Institutional
research profile
The main goal
of the institute is to identify causes and mechanisms underlying severe mental
disorders. The institute has been a major driver in using array and NGS
techniques to identify highly significant and replicated CNVs, point mutations
and SNPs. Most recently, the institute has worked to convert these findings
into actionable biological insight applying multi-OMICs technologies to
biomaterial from the unique, nation-wide Danish biobanks and transgenic animal
models, and through genomic-guided clinical studies in humans. This work is
part of iPSYCH Initiative for
Integrative Psychiatric Research sponsored by the Lundbeck Foundation (www.ipsych.dk)
and involves multiple international academic and industrial groups.
Job profile
The lead
scientist will be primary responsible for a large project within the iPSYCH
portfolio (see below), including overall project management and coordination of
internal and external collaborators. Once established the lead scientist is
extended to build and lead a research group around the project. It is expected
that the lead scientist contributes conceptually and practically to projects
driven by colleagues at the Institute or at collaborating institutions. The position includes supervision of students
and participation in the development of the institute's research profile. The
lead scientist will report to the director of the Institute, Professor Thomas
Werge.
Qualifications
Professional qualifications:
- A relevant PhD degree and prior academic employment at the level corresponding to associate professor
- Internationally leading in genomics, bioinformatics or systems biology
- Excellent collaborative, communication and presentation skills
- Experience from teaching and supervision
Personal
qualifications:
- Strong drive to obtain established goals
- Scientifically self-propelling and creative
- Ability to work independently and structured
- Open-minded and analytical personality
iPSYCH research program
The iPSYCH
Initiative was established in 2012 through a donation by the Lundbeck
Foundation of 121 million DKK for an initial three year period - the largest
grant ever to Danish psychiatric research - and recently extended for another
three years to 2021 through an identical grant. The iPSYCH initiative will
study five mental disorders: autism, ADHD, schizophrenia, bipolar disorder and
depression. It will capitalize on the comprehensive Danish civil and health
registers and biobanks to provide population structure, clinical information
and biomaterial for multi-OMICs analysis. By summer 2014 the initiative have
generated SNP-array and NGS data on more than 85,000 DNA samples to be combined
with extensive register-data on environmental exposures and phenotypic data
from hospital registers. Ongoing work is aiming to perform metabolomics and
possibly transcriptomics on the same neonatal blood spots. In parallel clinical
and translational studies are being conduction on patients and transgenic
animals. The lead scientist will work to combine these multilayer-OMICs data
with environmental exposures and comprehensive clinical phenotypes to
disentangle disease causes and mechanisms.
Collaborating
institutions
iPSYCH
partners also include Mental
Health Centre Copenhagen, Capital Region of Denmark, Department of Biomedicine, Aarhus University, Denmark, National Centre for Register-based
Research, Aarhus University, Denmark, Department
of Clinical Medicine, Aarhus University and Aarhus University Hospital, Risskov
Danish collaborators include
The Lundbeck Foundation
Center of Medical Genomics and The Novo Nordisk Foundation Center For Basic
Metabolic Research, University of Copenhagen, Danish Research Centre Magneic Research, Copenhagen University Hospital, Department
of Clinical Biochemistry and Immunology, Statens Serum Institute, Denmark, Department of Systems
Biology, Technical University of Denmark, Department of Clinical Immunology and the
Danish Blood Donors, Rigshospitalet, Department of Biology, University of
Copenhagen, Synaptic transmission. H. Lundbeck A/S.
International
collaborator include deCODE genetics, Oslo University Hospital, Psychiatric
Genomics Consortium, BROAD Institute of MIT and Harvard, and Swiss Federal
Institute of Technology Zürich.
We offer
Institute of Biological Psychiatry offers an interesting, challenging, multidisciplinary
and increasingly international research environment in an informal and social
atmosphere. We are currently 30 academic, technical and
administrative employees, plus medical and science students. The institute is
an independent research unit under the Mental Health Services in Copenhagen
(part of Copenhagen University Hospital) and affiliated with Medical School of
the University of Copenhagen. The institute runs a modern molecular genetics
laboratory and hosts the Danish Psychiatric Biobank.
Salary and terms of employment
The
appointment will be based on the collective agreement with the Confederation of
Professional Associations. The allowance will be agreed with the relevant
union. The employment will initially be for a period of three years based on a
full-time appointment (37 hours per week) with the expectation of extension.
The place of work is at the Institute of Biological Psychiatry at the Mental
Health Center Sct. Hans located in Roskilde just west of Copenhagen. The
institute will be able to provide accommodation at the hospital campus. Researchers recruited from abroad may be
eligible to receive a tax reduction for a limited period (See http://ism.ku.dk/taxes/ for more information
of tax reduction).
Further information
Further
information may be obtained from the director of the institute, Professor
Thomas Werge at telephone no. (+45) 38 64 22 80 or e-mail: thomas.werge@regionh.dk
Application
We encourage
submission of applications as soon as possible and no later than January 24,
2018. The application must be submitted as one PDF file and include the
following appendices in the order mentioned below. All materials must be in
English:
- Application referring specifically to the job profile and iPSYCH research program
- Curriculum vitae, specifying work experience with specific OMICs data and program languages.
- List of peer reviewed publications
- Diplomas for academic degrees and other relevant documentation
Applications
that do not fulfill the requirements will be rejected, without further
explanations or notifications. Job
interviews will be held as soon as possible after receipt of the application.
For residents outside Denmark, initial interviews will be held using SKYPE or
similar arrangement. All interested candidates irrespective of age, gender,
disability, race, religion or ethnic background are encouraged to apply.
-
Jobbet er udløbet...
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- Læs om regionen
Fakta
- Arbejdssted
Region Hovedstadens Psykiatri - Adresse
Boserupvej 2, 4000 Roskilde -
Kontaktperson
Thomas Mears Werge - Stillingstype
Forsker - Speciale
Psykiatri - Ansættelsesform
Projektansættelse - Ugentlig arbejdstid
Fuld tid - Ansættelsens start
01-03-2018 - Regionens jobnr.
209470 - Quick-nr.
327429 - Indrykningsdato
08-01-2018 -
Ansøgningsfrist
24-01-2018 (udløbet)
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