PhD student position in clinical trial on anti-viral effects of macrolide treatment in asthma and COPD patients
A PhD position is available in the
Respiratory Research Unit of the Pulmonary Dept. at Bispebjerg Hospital,
Copenhagen.
The
project
The AZIMUNE project answers an important
question regarding macrolide treatment in asthma and COPD: How does it work,
and who does it work in? AZIMUNE is an ambitious translational research project
conducted in a strong collaboration between internationally recognized research
groups with asthma and COPD, immunology and microbiology.
Long-term treatment with low-dose macrolide
antibiotics (e.g. Azithromycin) has been proven effective in preventing exacerbations
in asthma and COPD. The underlying mechanisms of this effect are unknown, but
could be related to an improved immune defense against virus, as well as a
reduction in the airway inflammation caused by the virus and/or microbial
community. Macrolides do not work in all patients, and it is important to identify
subgroups of patients most likely to respond.
The AZIMUNE project, an investigator initiated
randomized placebo-controlled trial, will describe the effects of macrolide
treatment on the anti-viral immune defense in asthma and COPD, as well as the
anti-inflammatory and anti-microbial effects. This will be primarily studied by
bronchoscopy acquired bronchial epithelial cell responses to in vitro
challenges with rhinovirus. The project is a collaboration between Bispebjerg
Hospital and the university of Lund (Sweden).
We
offer
The successful candidate will be part of a
dynamic research team consisting of pulmonologists, post-docs, basic
scientists, and other PhD students.
The candidate will have the opportunity to
develop skills in respiratory medicine ranging from performing lung function
tests to bronchoscopies.
The applicant will take active part in
research seminars and conferences.
Responsibilities
and tasks
The PhD student will be responsible for preparing
the study protocol, recruitment of patients, the logistics of the trial, and
actively participate in non-invasive diagnostics as well as bronchoscopy
studies.
Qualifications
The candidate (MD) will have
qualifications, experience and/or strong interest within one or several of the
following areas:
- Minimal 1 year clinical experience
- Research experience
- Have a genuine interest in respiratory medicine and research
- Be independent and ambitious
- Possess good interpersonal skills
- Have great organizational capacities
Formal
requirements
To be accepted for the position, it is
required to have a degree as – or considered to be equivalent to – a Danish
Medical Doctor and have an authorization to work as a Danish Medical Doctor.
You must also be proficient in Danish.
It is a prerequisite that the PhD candidate
is enrolled as a PhD student at the Faculty of Health and Medical Sciences.
Terms
of salary and employment
The salary and appointment terms will be as
a clinical assistant according to the Agreement for Junior Doctors as set out
in Regionernes Lønnings- og Takstnævn. The candidate will be employed at the
Respiratory Research Unit, Bispebjerg Hospital.
Supervisor/start
date
The primary supervisor will be Professor
and Senior Consultant Celeste Porsbjerg. In addition, Post-doc and Senior
Consultant Therese Lapperre will co-supervise the candidate.
The position is full-time, starting summer
2019.
Application
The application must be in English and
include the following documents/attachments:
- Motivated letter of application
- Curriculum vitae
- A certified/signed copy of MD certificate
- A complete list of publications and conference presentations
The application must be submitted
electronically through the link.
Questions
For further questions please contact
Therese Lapperre, e-mail: therese.sophie.lapperre@regionh.dk.
Assessment of the applicants will be made
on the basis of an interview with the study team.
-
Jobbet er udløbet...
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Fakta
- Arbejdssted
Bispebjerg og Frederiksberg Hospital - Adresse
Bispebjerg Bakke 23, 2400 København NV -
Kontaktperson
Therese Sophie Lapperre - Stillingstype
Forsker - Speciale
Intern medicin: Lungesygdomme - Ansættelsesform
Tidsbegrænset periode - Ugentlig arbejdstid
Fuld tid - Ansættelsens start
01-06-2019 - Regionens jobnr.
216637 - Quick-nr.
363050 - Indrykningsdato
06-02-2019 -
Ansøgningsfrist
15-03-2019 (udløbet)
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